MIN — Panadol, general information, pharmacology, Panadol for patients, Panadol interactions, Panadol contraindications, additional information about Panadol. Panadol - General Information. Analgesic antipyretic derivative of acetanilide. It has weak anti- inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. Pub. Chem]Pharmacology of Panadol.
Panadol (USAN) or Paracetamol (INN) is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Panadol, unlike other common analgesics such as aspirin and ibuprofen, has no anti- inflammatory properties or effects on platelet function, and so it is not a member of the class of drugs known as non- steroidal anti- inflammatory drugs or NSAIDs. In normal doses acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, the kidneys, or the fetal ductus arteriosus (as NSAIDs can). Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way. Panadol and NSAIDs have the benefit of being completely free of problems with addiction, dependence, tolerance and withdrawal.
- Панадол (Panadol). Действующее вещество: парацетамол. Внутрь взрослым панадол назначают в разовой дозе 500 мг (максимальная разовая доза - 1 г). Кратность назначения - до 4 раз в сутки..
- Панадол. Инструкция по. Это фирменный вариант знакомого уже не один год парацетамола. Сироп панадол инструкция. При лечении сиропом панадол нужно особое внимание уделять состоянию печени пациента.
- Panadol (USAN) or Paracetamol (INN) is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics.
- Инструкция на Панадол. ИНСТРУКЦИЯ. по медицинскому применению препарата. ПАНАДОЛ. Регистрационный номер: П N014409/01.
Panadol is used on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone. Panadol for patients. Do not use the maximum dosage of this product for more than 1. Do not take the product for pain for more than 1. If pain or fever persists.
Полная информация по препарату Панадол: инструкция, применение, цены, наличие в аптеках, подбор заменителей, отзывы и консультации специалистов. » Описание препарата, инструкция по применению. Geralgin – K Состав: парацетамол, кофеин, кодеин-фосфат. Nurofen, Nurofen Cold flu, суспензия Ultrafen (действующее вещество Как правило, инструкции к медицинским препаратам написаны на турецком.
Do not use with other. Do not use if carton is opened. Keep this and all medication out of The reach of children. As with any drug, if you are pregnant or nursing A baby, seek the advice of a health. In the case of accidental overdose, contact a. Center immediately.
Prompt medical attention is critical for. Well as for children even if you do not notice any signs or symptoms.
Panadol Interactions. Panadol Contraindications. Acetaminophen should not be administered to patients who have previously exhibited hypersensitivity to it. Additional information about Panadol. Panadol Indication: For temporary relief of fever and minor aches and pains. Mechanism Of Action: Panadol is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX- 1 and COX- 2, enzymes involved in prostaglandin (PG) synthesis.
Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti- inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme's active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX- 1 and COX- 2.
This enzyme is now referred to as COX- 3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. Drug Interactions: Anisindione Panadol increases the anticoagulant effect. Warfarin Panadol increases the anticoagulant effect. Imatinib Increased hepatic toxicity of both agents. Isoniazid Risk of hepatotoxicity.
Dicumarol Panadol increases the anticoagulant effect. Dicumarol Increases the anticoagulant effect. Acenocoumarol Increases the anticoagulant effect. Food Interactions: Take without regard to meals. Avoid alcohol (may increase risk of hepatotoxicity). Generic Name: Acetaminophen. Synonyms: Paracetanol; APAP; Acetaminofen; Paracetamolo; Paracetamol.
Drug Category: Analgesics, Non- Narcotic; Antipyretics. Drug Type: Small Molecule; Approved. Other Brand Names containing Acetaminophen: Abenol; Abensanil; Acamol; Accu- Tap; Acephen; Aceta Elixir; Aceta Tablets; Acetagesic; Acetalgin; Actamin; Actimol; Algotropyl; Allay; Alpiny; Alpinyl; Alvedon; Amadil; Aminofen; Anacin; Anacin- 3; Anaflon; Anapap; Anelix; Anhiba; Apacet; Apadon; Apamid; Apamide; Atasol; Banesin; Bayer Select; Bickie- mol; Bucet; Butapap; Calpol; Captin; Cetadol; Clixodyne; Co- Gesic; Conacetol; Dafalgan; Dapa; Dapa X- S; Darvocet; Datril; Dimindol; Dirox; Disprol; Dolene AP- 6. Doliprane; Dolprone; Drixoral Plus; Dularin; Dymadon; Dypap; Elixodyne; Enelfa; Eneril; Eu- Med; Excedrin; Exdol; Febridol; Febrilix; Febrinol; Febro- Gesic; Febrolin; Fendon; Feverall; Fevor; Finimal; Gelocatil; Genapap; Genebs; Hedex; Homoolan; Hy- Phen; Injectapap; Janupap; Korum; Lestemp; Liquagesic; Liquiprin; Lonarid; Lyteca; Momentum; Multin; NAPA; Napafen; Napap; Naprinol; Nealgyl; Nebs; Neopap; Neotrend; Nobedon; Norco; Oraphen- PD; Ortensan; Pacemo; Painex; Paldesic; Panadol; Panaleve; Panasorb; Panets; Panex; Panofen; Papa- Deine; Paracet; Parapan; Paraspen; Parelan; Parmol; Pasolind; Pasolind N; Pedric; Phenaphen; Phenaphen Caplets; Phendon; Phrenilin; Phrenilin Forte; Prompt; Propacet 1. Proval; Absorption: Rapid and almost complete.
Toxicity (Overdose): Oral, mouse: LD5. Oral, rat: LD5. 0 = 1. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with sulfate and glucuronide, and then excreted by the kidneys. Only a small portion is metabolized via the hepatic cytochrome P4. The toxic effects of acetaminophen are due to a minor alkylating metabolite (N- acetyl- p- benzo- quinone imine), not acetaminophen itself nor any of the major metabolites. This toxic metabolite reacts with sulfhydryl groups.
At usual doses, it is quickly detoxified by combining irreversibly with the sulfhydryl group of glutathione to produce a non- toxic conjugate that is eventually excreted by the kidneys. The toxic dose of paracetamol is highly variable. In adults, single doses above 1. In adults, single doses of more than 2. Protein Binding: 2. Biotransformation: Approximately 9. P4. 50 enzyme pathways (primarily by conjugation with glucuronic acid, sulfuric acid, and cysteine).
An intermediate metabolite is hepatotoxic and most likely nephrotoxic and can accumulate after the primary metabolic pathways have been saturated. Half Life: 1 to 4 hours. Dosage Forms of Panadol: Tablet Oral. Tablet, effervescent Oral. Tablet, extended release Oral.
Suspension Oral. Capsule Oral. Solution Oral. Liquid Oral. Elixir Oral. Suppository Rectal. Syrup Oral. Solution / drops Oral. Chemical IUPAC Name: N- (4- hydroxyphenyl)acetamide.
Chemical Formula: C8. H9. NO2. Acetaminophen on Wikipedia: http: //en. Acetaminophen. Organisms Affected: Humans and other mammals.